COMPARISON OF CEREBROVASCULAR REACTIVITY TESTS: A PILOT HUMAN STUDY


Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds.

Adenoviral gene therapy and oncolysis would critically benefit from targeted cell entry by genetically modified capsids.This requires both the ablation of native adenovirus tropism and the identification of ligands that remain functional in virus context.Here, we establish cell type-specific entry of HAdV-5-based vectors by genetic ligand insertion

read more



Comparative genomic analysis of multi-subunit tethering complexes demonstrates an ancient pan-eukaryotic complement and sculpting in Apicomplexa.

Apicomplexa are obligate intracellular parasites that cause tremendous disease burden world-wide.They utilize a set of specialized secretory organelles in their invasive process here that require delivery of components for their biogenesis and function, yet the precise mechanisms underpinning such processes remain unclear.One set of potentially imp

read more